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[1]陈瑞,王煜倩,周兴藩,等.工作场所超细颗粒物暴露评估与风险评估研究进展*[J].中国安全生产科学技术,2022,18(2):75-80.[doi:10.11731/j.issn.1673-193x.2022.02.011]
　CHEN Rui,WANG Yuqian,ZHOU Xingfan,et al.Research progress on exposure assessment and risk assessment of ultrafine particles in workplace[J].JOURNAL OF SAFETY SCIENCE AND TECHNOLOGY,2022,18(2):75-80.[doi:10.11731/j.issn.1673-193x.2022.02.011]
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工作场所超细颗粒物暴露评估与风险评估研究进展*
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《中国安全生产科学技术》[ISSN:1673-193X/CN:11-5335/TB]

卷:
18
期数:
2022年2期
页码:
75-80
栏目:
学术论著
出版日期:
2022-02-28

文章信息/Info

Title:
Research progress on exposure assessment and risk assessment of ultrafine particles in workplace
文章编号:
1673-193X(2022)-02-0075-06
作者:
陈瑞; 王煜倩; 周兴藩; 唐仕川
（北京市科学技术研究院城市安全与环境科学研究所 职业安全健康北京市重点实验室，北京 100054）
Author(s):
CHEN Rui;  WANG Yuqian;  ZHOU Xingfan;  TANG Shichuan
（Beijing Key Laboratory of Occupational Safety and Health,Institute of Urban Safety and Environmental Science,Beijing Academy of Science and Technology,Beijing 100054,China）
关键词:
超细颗粒物; 纳米材料; 暴露监测; 风险评估; 职业健康
Keywords:
ultrafine particle;  nanomaterials;  exposure monitoring;  risk assessment;  occupational health
分类号:
X961
DOI:
10.11731/j.issn.1673-193x.2022.02.011
文献标志码:
A
摘要:
纳米技术产业的快速发展促使纳米材料需求量不断增长，纳米材料的规模化生产及使用，增加了暴露于超细颗粒物的职业人群数量，且工种复杂多样,尤其在自动化程度低、工人职业卫生防护意识薄弱的作业场所，对接触者有潜在的职业暴露风险。从现场暴露评估策略、检测方法、接触限值以及风险评估手段，综述针对超细颗粒物这一新型职业危害因素的研究进展，讨论目前存在的问题，总结推进职业健康管理的方法。研究表明：可为促进纳米生产及使用企业作业环境改善，保护纳米颗粒物暴露人群健康，推动纳米材料健康风险认知及控制技术发展提供参考。
Abstract:
The rapid development of the nanotechnology industry has led to the continuous increase in the demand for nanomaterials.The large-scale production and use of nanomaterials has increased the number of occupational groups exposed to ultrafine particles,and the types of work are complex and diverse.Especially in workplaces with low degree of automation and weak awareness of occupational health protection among workers,there are potential occupational exposure risks to contacts.From on-site exposure assessment strategies,detection methods,exposure limits and risk assessment methods,the research progress of ultrafine particles,a new occupational hazard factor,is reviewed,the current problems are discussed,and the methods for promoting occupational health management are summarized.The research shows that it can provide a reference for promoting the improvement of the working environment of nano-production and use enterprises,protecting the health of people exposed to nano-particles,and promoting the development of nano-material health risk awareness and control technology.

参考文献/References:

［1］CHEN Rui,YIN Hong,COLEIVAN S,et al.Exposure,assessment and health hazards of particulate matter in metal additive manufacturing:A review ［J］.Chemosphere,2020,259:127452.
［2］CHEN Rui,HU Bin,LIU Ying,et al.Beyond PM2.5:The role of ultrafine particles on adverse health effects of air pollution ［J］.Biochimica et Biophysica Acta-General Subjects,2016,1860(12):2844-2855.
［3］PIETROIUSTI ANTONIO,STOCKMANN-JUVALA HELENE,LUCARONI FRANCESCA,et al.Nanomaterial exposure,toxicity,and impact on human health ［J］.Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnolgy,2018,10(5):e1513.
［4］XING Mingluan,ZHANG Yuanbao,ZOU Hua,et al.Exposure characteristics of ferric oxide nanoparticles released during activities for manufacturing ferric oxide nanomaterials ［J］.Inhalation Toxicology,2015,27(3):138-148.
［5］SHEN Jingcao,YANG Dan,ZHOU Xingfan,et al.Role of autophagy in zinc oxide nanoparticles-induced apoptosis of mouse leydig cells ［J］.International Journal of Molecular Sciences,2019,20(16) pii:E4042.
［6］CHEN Rui,QIAO Jiyan,BAI Ru,et al.Intelligent testing strategy and analytical techniques for the safety assessment of nanomaterials ［J］.Analytical and Bioanalytical Chemistry,2018,410(24):6051-6066.
［7］CHEN Rui,LING Daishun,ZHAO Lin,et al.Parallel comparative studies on mouse toxicity of oxide nanoparticle and gadolinium-based T1 mri contrast agents ［J］.ACS Nano,2015,9(12):12425-12435.
［8］CHEN Rui,HUO Lingling,SHI Xiaofei,et al.Endoplasmic reticulum stress induced by zinc oxide nanoparticles is an earlier biomarker for nanotoxicological evaluation ［J］.ACS Nano,2014，8(3):2562-2574.
［9］XING Qisong,WU Meiqiong,CHEN Rui,et al.Comparative studies on regional variations in PM2.5 in the induction of myocardial hypertrophy in mice ［J］.Science of the Total Environment,2021,775:145179.
［10］BHUSHAN BHARAT.Springer handbook of nanotechnology,Fourth Edition ［M］.Berlin:Springer Nature,2017.
［11］CHEN Rui,ZHAO Lin,BAI Ru,et al.Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues:Implications for the development of acute toxicity after intravenous administration ［J］.Toxicology Research,2016,5(2):602-608.
［12］陈春英,陈瑞,白茹,等.生产与工作场所纳米颗粒暴露监测指南［M］.北京:科学出版社，2015.
［13］OBERDRSTER Günter.Toxicology of ultrafine particles:In vivo studies ［J］.Philosophical Transactions of The Royal Society A Mathematical Physical and Engineering Sciences,2000,358(1775):2719-2740.
［14］ZOU Hua,ZHANG Qunwei,XING Mingluan,et al.Relationships between number,surface area,and mass concentrations of different nanoparticles in workplaces［J］.Environmental Science Processes & Impacts,2015,17(8):1470.
［15］LI Guoliang,LIANG Lihong,YANG Jingchao,et al.Pulmonary hypofunction due to calcium carbonate nanomaterial exposure in occupational workers:A cross-sectional study ［J］.Nanotoxicology,2018,12(6):571-585.
［16］中华人民共和国国家卫生健康委员会.工作场所空气中粉尘测定第6部分:超细颗粒物和细颗粒物总数量浓度：GBZ/T 192.6—2018［S］.北京:中国标准出版社,2018.
［17］张美辨,唐仕川.工作场所纳米颗粒暴露监测评估及控制技术［M］.北京:中国环境出版集团,2018.
［18］中华人民共和国国家质量监督检验检疫总局，中国国家标准化管理委员会.纳米技术 纳米技术职业场所健康和安全指南:GB/T 33715—2017［S］.北京:中国标准出版社,2017.
［19］唐仕川,常兵.工程纳米材料职业健康与安全［M］.北京:科学出版社,2015.
［20］崔玲,沈臻霖,唐仕川.纳米颗粒暴露评价研究综述［J］.中国安全科学学报,2011,21(7):130-137.CUI Ling,SHEN Zhenlin,TANG Shichuan.Review on nanoparticle exposure assessment research［J］.China Safety Science Journal,2011,21(7):130-137.
［21］SCHMOLL L H,PETERS T M,and O’SHAUGHNESSY P T,Use of a condensation particle counter and an optical particle counter to assess the number concentration of engineered nanoparticles ［J］.Journal of Occupational & Environmental Hygiene,2010.7(9):535-545.
［22］NIOSH.Current Intelligence Bulletin 63:Occupational Exposure to Titanium Dioxide［EB/OL］.https://www.cdc.gov/niosh/docs/2011-160/,2011.
［23］NIOSH.Current Intelligence Bulletin 65:Occupational Exposure To Carbon Nanotubes and Nanofibers ［EB/OL］.https://www.cdc.gov/niosh/docs/2013-145/pdfs/2013-145.pdf?id=10.26616/NIOSHPUB2013145,2013.
［24］NIOSH.Current Intelligence Bulletin 70:Health Effects of Occupational Exposure to Silver Nanomaterials［EB/OL］.https://www.cdc.gov/niosh/docket/archive/pdfs/niosh-260a/2021-112_508_May2021.pdf,2021.
［25］IFA.Criteria for assessment of the effectiveness of protective measures［EB/OL］.https://www.dguv.de/ifa/fachinfos/nanopartikel-am-arbeitsplatz/beurteilung-von-schutzmassnahmen/index-2.jsp,2009.
［26］GAO Xiangjiang,ZOU Hua,ZHOU Zanrong,et al.Qualitative and quantitative differences between common control banding tools for nanomaterials in workplaces ［J］.RSC Advances,2019.9(59):34512-34528.
［27］国家市场监督管理局，中国国家标准化管理委员会.纳米技术 工程纳米材料的职业风险管理 第2部分：控制分级方法应用:GB/T 38091.2—2019/ISO/TS 12901—2:2014［S］.北京:中国标准出版社,2019.
［28］DIMOU KAOTAR and EMOND CLAUDE.Nanomaterials,and occupational health and safety—a literature review about control banding and a semi-quantitative method proposed for hazard assessment ［J］.Journal of Physics Conference,2017,838:012020.
［29］LIGUORI BIASE,HANSEN STEFFEN FOSS,BAUN ANDERS,et al.Control banding tools for occupational exposure assessment of nanomaterials-ready for use in a regulatory context?［J］.Nanoimpacts,2016,2:1-17.
［30］许志珍,王煜倩,郭玲,等.纳米材料职业风险评估控制分级方法分析［J］.中国工业医学杂志,2020,33(1):39-42.XU Zhizhen,WANG Yuqian,GUO Ling,et al.Assessment methods of occupational risk for nanomaterials ［J］.Chinese Journal of Industrial Medicine,2020,33(1):39-42.
［31］WANG Yuqian,CHEN Rui,ZHOU Xingfan,et al.Risk assessment of nanoparticle exposure in a calcium carbonate manufacturing workshop with six control banding tools ［J］.Journal of Nanoscience and Nanotechnology,2020,20(6):3610-3619.
［32］ERDELY AARON,DAHM MATTHEW,CHEN BEAN T,et al.Carbon nanotube dosimetry:From workplace exposure assessment to inhalation toxicology ［J］.Particle and Fibre Toxicology,2013.10(1):53.
［33］WANG Ruixia,CHEN Rui,WANG Youfeng,et al.Complex to simple:In vitro exposure of particulate matter simulated at the air-liquid interface discloses the health impacts of major air pollutants ［J］.Chemosphere,2019,223:263-274.
［34］BOYES WILLIAM K,CHEN Rui,CHEN Chunying,et al.The neurotoxic potential of engineered nanomaterials ［J］.Neurotoxicology,2012,33(4):902-910.
［35］OBERDRSTER G,SHARP Z,ATUDOREI V,et al.Translocation of inhaled ultrafine particles to the brain ［J］.Inhalation Toxicology,2004,16(6-7):437-445.
［36］SHANG Yidan,CHEN Rui,BAI Ru,et al.Quantification of long-term accumulation of inhaled ultrafine particles via human olfactory-brain pathway due to environmental emissions-a pilot study ［J］.NanoImpact,2021,22:100322.
［37］TIAN Lin,SHANG Yidan,CHEN Rui,et al.Correlation of regional deposition dosage for inhaled nanoparticles in human and rat olfactory ［J］.Particle and Fibre Toxicology,2019,16(1):6.
［38］TIAN Lin,SHANG Yidan,CHEN Rui,et al.A combined experimental and numerical study on upper airway dosimetry of inhaled nanoparticles from an electrical discharge machine shop ［J］.Particle and Fibre Toxicology,2017,14(1):24.

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备注/Memo

备注/Memo:
收稿日期： 2021-12-06
* 基金项目： 国家自然科学基金项目（21777036）；首都卫生发展科研专项项目（首发2021-1G-1191）；北京市科学技术研究院财政项目（11000022T000000445556，11000022T000000468169）
作者简介： 陈瑞，博士，研究员，主要研究方向为卫生毒理学。
通信作者： 唐仕川，硕士，研究员，主要研究方向为劳动卫生与职业病。
更新日期/Last Update: 2022-03-18